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BASF Metabolome Solutions GmbH

Publications

de Bruijn V, Behr C, Sperber S, Walk T, Ternes P, Slopianka M, Haake V, Beekmann K, van Ravenzwaay B (2020): Antibiotic-induced changes in microbiome-related metabolites and bile acids in rat plasma. Metabolites 10, 242. doi: 10.3390/metabo10060242.

Kong J, Martin-Ortigosa S, Finer J, Orchard N, Gunadi A, Batts LA, Thakare D, Rush B, Schmitz O, Stuiver M, Olhoft P, Pacheco-Villalobos D (2020): Overexpression of the transcription factor GROWTH-REGULATING FACTOR5 improves transformation of dicot and monocot species. Frontiers in Plant Science. https://doi.org/10.3389/fpls.2020.572319.

Brabham C, Johnen P, Hendriks J, Betz M, Zimmermann A, Gollihue J, Serson W, Kempinski C, Barrett M (2020): Herbicide symptomology and the mechanism of action of methiozolin. Weed Science 69, 18-30. https://doi.org/10.1017/wsc.2020.87

Allaway D, Gilham M, Wagner-Golbs A, González Maldonado S, Haydock R, Colyer A, Stockman J, Watson P (2019): Metabolomic profiling to identify effects of dietary calcium reveal the influence of the individual and postprandial dynamics on the canine plasma metabolome. Journal of Nutritional Science 8: e13. doi: 10.1017/jns.2019.12.

Behr C, Slopianka M, Haake V, Strauss V, Sperber S, Kamp H, Walk T, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2019): Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats. Toxicology and Applied Pharmacology 363, 79-87.

Keller J, Mellert W, Sperber S, Kamp H, Jiang X, Fabian E, Herold M, Walk T, Strauss V, van Ravenzwaay B (2019): Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies. Toxicology Letters 301, 42-52.

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han S, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Shimano H (2019): Hepatocyte ELOVL fatty acid elongase 6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice. Hepatology 71, 1609-1625.

Meyer RC, Gryczka C, Neitsch C, Müller M, Bräutigam A, Schlereth A, Schön H, Weigelt-Fischer K, Altmann T (2019): Genetic diversity for nitrogen use efficiency in Arabidopsis thaliana. Planta 250, 41-57.

Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE,  Witt H, González Maldonado S, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer JS, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N. (2019): Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure. Cardiovascular Research 115, 1296-1305.

Rein D, Ternes P, Demin R, Gierke J, Helgason T, Schön C (2019): Artificial intelligence identified peptides modulate inflammation in healthy adults. Food & Function 10, 6030-6041.

Sperber S, Wahl M, Berger F, Kamp H, Lemke O, Starck V, Walk T, Spitzer M, van Ravenzwaay B (2019): Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol. Regulatory Toxicology and Pharmacology 108,104442. doi:10.1016/j.yrtph.2019.104442

Viant MR, Ebbels TMD, Beger RD, Ekman DR, Epps DJT, Kamp H, Leonards PEG, Loizou GD, MacRae JI, van Ravenzwaay B, Rocca-Serra P, Salek RM, Walk T, Weber RJM (2019): Use cases, best practice and reporting standards for metabolomics in regulatory toxicology. Nature Communications 10, 3041. https://doi.org/10.1038/s41467-019-10900-y

Beatty A, Fink LS, Singh T, Strigun A, Peter E, Ferrer CM, Nicolas E, Cai KQ, Moran TP, Reginato MJ, Rennefahrt U, Peterson JR (2018): Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple-negative breast cancer. Molecular Cancer Therapeutics 17, 264-275.

Behr C, Sperber S, Jiang X, Strauss V, Kamp H, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2018): Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics. Toxicology and Applied Pharmacology 355, 198-210.

Behr C, Ramirez-Hincapie S, Cameron HJ, Strauss V, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2018): Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces. Toxicology Letters 296, 139-151.

Campe R, Hollenbach E, Kämmerer L, Hendriks J, Höffken HW, Kraus H, Lerchl J, Mietzner T, Tresch S, Witschel M, Hutzler J (2018): A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis. Pesticide Biochemistry and Physiology 148, 116-125.

Kamlage B, Neuber S, Bethan B, González Maldonado S, Wagner-Golbs A, Peter E, Schmitz O, Schatz P (2018): Impact of prolonged blood incubation and extended serum storage at room temperature on the human serum metabolome. Metabolites 8, 6; https://doi.org/10.3390/metabo8010006

Langsch A, David RM, Schneider S, Sperber S, Haake V, Kamp H, Leibold E, van Ravenzwaay B, Otter R (2018): Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties. Toxicology Letters 288, 99-110.

Mayerle J, Kalthoff H, Reszka R, Kamlage B, Peter E, Schniewind B, González Maldonado S, Pilarsky C, Heidecke C-D, Schatz P, Distler M, Scheiber JA, Mahajan UM , Weiss FU, Grützmann R, Lerch MM, (2018): Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis. Gut 67, 128-137.

McGranaghan P, Rennefahrt U, Kamlage B, Reszka R, Schatz P, Bethan B, Mayerle J, Lerch MM, (2018): Approaching Pancreatic Cancer Phenotypes via Metabolomics. In: Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MS (eds.): Pancreatic Cancer, pp. 1305-1324, Springer, New York, NY.

Ramirez T, Strigun A, Verlohner A, Huener HA, Peter E, Herold M, Bordag N, Mellert W, Walk T, Spitzer M, Jiang XQ, Sperber S, Hofmann T, Hartung T, Kamp H, van Ravenzwaay B (2018): Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells. Archives of Toxicology 92, 893-906.

Sperber S, Birk B, Haake V, Walk T, van Ravenzwaay B, Kamp H (2018): Differentiation of hepatotoxic compounds by metabolomics in HepG2 cells. Toxicology Letters 295, S123-S124. 

Behr C, Kamp H, Fabian E, Krennrich G, Mellert W, Peter E, Strauss V, Walk T, Rietjens I, van Ravenzwaay B (2017): Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats. Archives of Toxicology 91, 3439-3454.

Haufe S, Engele S, Kaminski J, Witt H, Rein D, Kamlage B, Utz W, Fuhrmann JC, Haas V, Mähler A, Schulz-Menger J, Luft FC, Boschmann M, Jordan J (2017): Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals. Nutrition, Metabolism and Cardiovascular Diseases 27, 858-864.

Mueller-Hennessen M, Düngen H-D, Lutz M, Trippel TD, Kreuter M, Sigl J, Müller OJ, Tahirovic E, Witt H, Ternes P, Carvalho S, Peter E, Rein D, Schatz P, Herth F, Giannitsis E, Weis T, Frey N, Katus HA (2017): A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction. Clinical Chemistry 63, 267-277.

Mueller-Hennessen M, Sigl J, Fuhrmann JC, Witt H, Reszka R, Schmitz O, Kastler J, Fischer JJ, Müller OJ, Giannitsis E, Weis T, Frey N, Katus HA (2017): Metabolic profiles in heart failure due to non-ischemic cardiomyopathy at rest and under exercise. ESC Heart Failure 4, 178-189.

Bordag N, Janakiraman V, Nachtigall J, González Maldonado S, Bethan B, Laine JP, Fux E (2016): Fast filtration of bacterial or mammalian suspension cell cultures for optimal metabolomics results. PLoS ONE 11, e0159389. https://doi.org/10.1371/journal.pone.0159389.

Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE, McManus V, Stefanski E, Martin S, Schatz P, Schrodi SJ (2016): Validation of a metabolite panel for early diagnosis of type 2 diabetes. Clinical Science 65, 1399-1408.

Dersch LM, Beckers V, Rasch D, Melzer G, Bolten C, Kiep K, Becker H, Bläsing OE, Fuchs R, Ehrhardt T, Wittmann C (2016): Novel approach for high-throughput metabolic screening of whole plants by stable isotopes. Plant Physiology 171, 25-41.

Fabian E, Bordag N, Herold M, Kamp H, Krennrich G, Looser R, Ma-Hock L, Mellert W, Montoya Parra G, Peter E, Prokudin A, Spitzer M, Strauss V, Walk T, Zbranek R, van Ravenzwaay B (2016): Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure. Toxicology Letters 255, 11-23.

Haufe S, Witt H, Engeli S, Kaminski J, Utz W, Fuhrmann JC, Rein D, Schulz-Menger J, Luft FC, Boschmann M, Jordan J (2016): Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects. Nutrition, Metabolism and Cardiovascular Diseases 26, 637-642.

Liu Y, Yieh L, Yang T, Drinkenburg P, Peeters P, Steckler T, Narayan V, Wittenberg G, Ye J (2016): Metabolomic biosignature differentiates melancholic depressive patients from healthy controls. BMC Genomics 17, 669. https://doi.org/10.1186/s12864-016-2953-2.

Meller S, Meyer HA, Bethan B, Dietrich D, González Maldonado S, Lein M, Montani M, Reszka R, Schatz P, Peter E, Stephan C, Jung K, Kamlage B, Kristiansen G (2016): Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer. Oncotarget 7, 1421-1438.

van Ravenzwaay B, Kamp H, Montoya Parra GA, Strauss V, Fabian E, Mellert W, Krennrich G, Walk T, Peter E, Looser R, Herold M (2016): The development of a database for metabolomics – looking back on ten years of experience. International Journal of Biotechnology 14, 47-68.

van Ravenzwaay B, Sperber S, Lemke O, Fabian E, Faulhammer F, Kamp H, Mellert W, Strauss V, Strigun A, Peter E, Spitzer M, Walk T (2016): Metabolomics as read-across tool: A case study with phenoxy herbicides. Regulatory Toxicology and Pharmacology 81, 288-304. 

Bordag N, Klie S, Jürchott K, Vierheller J, Schiewe H, Albrecht V, Tonn J-C, Schwartz C, Schichor C, Selbig J (2015): Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects. Scientific Reports 5, 15954. https://doi.org/10.1038/srep15954

Buesen R, Schulte S, Strauss V, Treumann S, Becker M, Gröters S, Carvalho S, van Ravenzwaay B (2015): Safety assessment of [3S, 3'S]-astaxanthin – Subchronic toxicity study in rats. Food and Chemical Toxicology 81, 129-136.

Gerlach N, Schmitz J, Polatajko A, Schlüter U, Fahnenstich H, Witt S, Fernie AR, Uroic K, Scholz U, Sonnewald U, Bucher M (2015):  An integrated functional approach to dissect systemic responses in maize to arbuscular mycorrhizal symbiosis. Plant, Cell & Environment 38,1591-1612.

Giesbertz P, Padberg I, Rein D, Ecker J, Höfle AS, Spanier B, Daniel H (2015): Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia 58, 2133-2143.

Kamp H, Fabian E, Frericks M, Herold M, Krennrich G, Looser R, Mellert W, Montoya Parra G, Peter E, Ramirez T, Spitzer M, Strauss V, Strigun A, Walk T, van Ravenzwaay B (2015): 10 years of metabolomics research: The importance of quality control. Toxicology Letters 238, S37-S37.

Montoya Parra G, Strauss V, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Spitzer M, Walk T, van Ravenzwaay B (2015): Metabolome differences in pregnancy and lactation compared to non-pregnant Wistar rats. Toxicology Letters 238, S229-S229. 

Buness A, Roth A, Herrmann A, Schmitz O, Kamp H, Busch K, Suter L (2014): Identification of metabolites, clinical chemistry markers and transcripts associated with hepatotoxicity. PLoS ONE 9. e97249. doi: 10.1371/journal.pone.0097249.

Helmering J, Juan T, Li C-M, Chhoa M, Baron W, Gyuris T, Richards W, Turk J, Lawrence J, Cosgrove P, Busby J, Kim K, Kaufman S, Cummings C, Carlson G,  Véniant M, Lloyd D (2014): A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids in Health and Disease 13,167. doi: 10.1186/1476-511X-13-167.

Hodgson A, Randell R, Mahabir-Jagessar-T K, Lotito S, Mulder T, Mela D, Jeukendrup A, Jacobs D (2014): Acute effects of green tea extract intake on exogenous and endogenous metabolites in human plasma. Journal of Agricultural and Food Chemistry 62, 1198-1208.

Mattes W, Davis K, Fabian E, Greenhaw J, Herold M, Looser R, Mellert W, Groeters S, Marxfeld H, Moeller N, Montoya Parra G, Prokoudine A, van Ravenzwaay B, Strauss V, Walk T, Kamp H (2014): Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology Letters 230, 467-478.

Mattes W, Kamp H, Strauss V, Fabian E, Montoya Parra G, Mellert W, Moeller N, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014): Metabolic profiling of hepatotoxic compounds in rats: relationship of predicted rodent to reported human phenotype. International Journal of Toxicology 33, 43-43.

Montoya Parra GA, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014a): Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicology Letters 225, 240-251.

Montoya Parra GA, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2014b): Qualitative and quantitative comparison of toxicological properties of racemates and their enantiomers with metabolomics. Toxicology Letters 229, S232-S232.

Montoya Parra GA, Strauss V, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Walk T, van Ravenzwaay B (2014): Sex-dependent metabolome changes in rats in response to different caloric intake. Toxicology Letters 229, S232-S232.

Nikiforova VJ, Giesbertz P, Wiemer J, Bethan B, Looser R, Liebenberg V, Ruiz Noppinger P, Daniel H, Rein D (2014): Glyoxylate, a new marker metabolite of type 2 diabetes. Journal of Diabetes Research 685204. doi: 10.1155/2014/685204.

Padberg I, Peter E, González Maldonado S, Witt H, Mueller M, Weis T, Bethan B, Liebenberg V, Wiemer J, Katus HA, Rein D, Schatz P (2014): A new metabolomic signature in type-2 diabetes mellitus and its pathophysiology. PLoS ONE 9(1), e85082. https://doi.org/10.1371/journal.pone.0085082

van Ravenzwaay B, Montoya Parra GA, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Peter E, Strauss V, Walk T, Kamp H (2014): The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective. Toxicology Letters 227, 20-28. 

Allaway D, Kamlage B, Gilham MS, Hewson-Hughes AK, Wiemer JC, Colyer A, Rein D (2013): Effects of dietary glucose supplementation on the fasted plasma metabolome in cats and dogs. Metabolomics 9, 1096-1108.

Duke S, Bajsa-Hirschel J, Pan Z (2013): Omics methods for probing the mode of action of natural and synthetic phytotoxins. Journal of Chemical Ecology 39, 333-347.

Jung K, Reszka R, Kamlage B, Bethan B, Stephan C, Lein M, Kristiansen G (2013): Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma. International Journal of Cancer 133, 2914-2924.

Kamlage B, González Maldonado S, Bethan B, Peter E, Schmitz O, Liebenberg V, Schatz P (2013): Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling. Clinical Chemistry 60, 399-412.

Mattes W, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, Mellert W, Prokoudine A, Strauss V, van Ravenzwaay B, Walk T, Naraoka H, Omura K, Schuppe-Koistinen I, Nadanaciva S, Bush ED, Moeller N, Ruiz Noppinger P, Piccoli SP (2013): Prediction of clinically relevant safety signals of nephrotoxicity through plasma metabolite profiling. BioMed Research International, 202497. doi: 10.1155/2013/202497

Mattes W, van Ravenzwaay B, Moeller N, Walk T, Ruiz Noppinger P, Kamp H (2013): Detection of idiosyncratic hepatotoxicity potential with metabolite profiling. International Journal of Toxicology 32, 70-71.

Montoya Parra G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2013a): Mechanistic explanation of different metabolomics patterns in rat plasma for the differentiation of direct thyroid hormone synthesis inhibitors and compounds increasing thyroid hormone clearance. Toxicology Letters 221, S193-S194.

Montoya Parra G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Looser R, Herold M, Krennrich G, Peter E, van Ravenzwaay B (2013b): Amiodarone: A metabolomic approach of different modes of action (MOAs) in rats. Toxicology Letters 221, S193-S193.

Ramirez T, Bordag N, Mellert W, Kamp H, Walk T, Looser R, van Ravenzwaay B (2013): Application of metabolomics in vitro for identification of toxicological modes of action. Toxicology Letters 221, S194-S194.

Schlüter U, Colmsee C, Scholz U, Bräutigam A, Weber AP, Zellerhoff N, Bucher M, Fahnenstich H, Sonnewald U (2013): Adaptation of maize source leaf metabolism to stress related disturbances in carbon, nitrogen and phosphorus balance. BMC Genomics 14, 442. doi: 10.1186/1471-2164-14-442.

Sun J, Ando Y, Ahlbory-Dieker D, Schnackenberg LK, Yang X, Greenhaw J, Pence L, Qian F, Salminen W, Mendrick DL, Beger RD (2013): Systems biology investigation to discover metabolic biomarkers of acetaminophen-induced hepatic injury using integrated transcriptomics and metabolomics. Journal of Molecular Biomarkers & Diagnosis, S1. doi: 10.4712/2155-9929.S1-002.

van Ravenzwaay B, Herold M, Kamp H, Montoya Parra G, Fabian E, Looser R, Krennrich G, Mellert W, Prokoudine A, Strauss V, Walk T, Wiemer J (2013): Metabolomics and REACH: quantitative biological activity relationships. Toxicology Letters 221, S27-S27.

van Ravenzwaay B, Kolle S, Ramirez T, Kamp H (2013): Vinclozolin: A case study on the identification of endocrine active substances in the past and a future perspective. Toxicology Letters 223, 271-279.

Colmsee C, Mascher M, Czauderna T, Hartmann A, Schlüter U, Zellerhoff N, Schmitz J, Bräutigam A, Pick TR, Alter P, Gahrtz M, Witt S, Fernie AR, Börnke F, Fahnenstich H, Bucher M, Dresselhaus T, Weber AP, Schreiber F, Scholz U, Sonnewald U (2012): OPTIMAS-DW: a comprehensive transcriptomics, metabolomics, ionomics, proteomics and phenomics data resource for maize. BMC Plant Biology 12, 245. doi: 10.1186/1471-2229-12-245.

Czech C, Berndt P, Busch K, Schmitz O, Wiemer J, Most V, Hampel H, Kastler J, Senn H (2012): Metabolite profiling of Alzheimer's Disease cerebrospinal fluid. PLoS ONE 7(2), 31501. doi: 10.1371/journal.pone.0031501

Grossmann K, Christiansen N, Looser R, Tresch S, Hutzler J, Pollmann S, Ehrhardt T (2012): Physionomics and metabolomics – two key approaches in herbicidal mode of action discovery. Pest Management Science 68, 494-504.

Grossmann K, Hutzler J, Tresch S, Christiansen N, Looser R, Ehrhardt T (2012): On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1,2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase. Pest Management Science 68, 482-492.

Gruden K, Hren M, Herman A, Blejec A, Albrecht T, Selbig J, Bauer C, Schuchardt J, Or-Guil M,  Zupančič K, Svajger U, Stabuc B, Ihan A, Kopitar AN, Ravnikar M, Knežević M, Rožman P, Jeras M (2012): A "crossomics" study analysing variability of different components in peripheral blood of healthy caucasoid individuals. PLoS One 7(1), doi: 10.1371/journal.pone.0028761.

Jacobs DM, Fuhrmann JC, van Dorsten FA, Rein D, Peters S, van Velzen EJJ, Hollebrands B, Draijer R, van Duynhoven J, Garczarek U (2012): Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome. Journal of Agricultural and Food Chemistry 60, 3078-3085.

Jacobs DM, Hodgson AB, Randell RK, Mahabir-Jagessar-T K, Garczarek U, Jeukendrup A, Mela DJ, Lotito S (2012): Metabolic response to decaffeinated green tea extract during rest and moderate-intensity exercise. Journal of Agricultural and Food Chemistry 62, 9936-9943.

Kamp H, Fabian E, Groeters S, Herold M, Krennrich G, Looser R, Mattes W, Mellert W,  Prokoudine A, Ruiz Noppinger P, Strauss V, Walk T, Wiemer J, van Ravenzwaay B (2012): Application of in vivo metabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity. Bioanalysis 4, 2291-2301.

Kamp H, Fabian E, Krennrich G, Leibold E, Mellert W, Strauss V, van Ravenzwaay B, Ahlbory-Dieker D, Herold M, Looser R, Prokoudine A, Walk T, Wiemer J (2012): The use of metabolomics in vivo for the development of agrochemical products. In: Jeschke P, Krämer W, Schirmer U, Witschel M (eds.): Modern Methods in Crop Protection Research. pp. 335-349. Wiley-VCH.

Kamp H, Strauss V, Wiemer J, Leibold E, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2012): Reproducibility and robustness of metabolome analysis in rat plasma of 28-day repeated dose toxicity studies. Toxicology Letters 215, 143-149.

Kolle SN, Ramirez T, Kamp H, Buesen R, Flick B, Strauss V, van Ravenzwaay B (2012): A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids. Regulatory Toxicology and Pharmacology 63, 259-278.

Maier A, Fahnenstich H, von Caemmerer S, Engqvist MK, Weber AP, Flügge UI, Maurino VG (2012): Transgenic introduction of a glycolate oxidative cycle into A. thaliana chloroplasts leads to growth improvement. Frontiers in Plant Science 3, 38. doi: 10.3389/fpls.2012.00038.

Ramirez T, Ahlbory-Dieker D, Fux E, Kamp H, Walk T, Wagner S, Looser R, van Ravenzwaay B (2012): Identification of liver toxicity by combining in vitro cell systems and metabolomics. Toxicology Letters 211, S160-S160.

Schlüter U, Mascher M, Colmsee C, Scholz U, Bräutigam A, Fahnenstich H, Sonnewald U (2012): Maize source leaf adaptation to nitrogen deficiency affects not only nitrogen and carbon metabolism but also control of phosphate homeostasis. Plant Physiology 160, 1384-1406.

Strauss V, Mellert W, Wiemer J, Leibold E, Kamp H, Walk T, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2012): Increased toxicity when fibrates and statins are administered in combination – A metabolomics approach with rats. Toxicology Letters 211, 187-200.

Tresch S, Heilmann M, Christiansen N, Looser R, Grossmann K (2012): Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. Phytochemistry 76, 162-171.

van Ravenzwaay B, Fabian E, Herold M, Kamp H, Looser R, Mellert W, Strauss V, Walk T, Wiemer J (2012): The identification of hypothyroid effects of amiodarone by metabolomics. Toxicology Letters 211, S160-S160.

van Ravenzwaay B, Herold M, Kamp H, Kapp MD, Fabian E, Looser R, Krennrich G, Mellert W, Prokoudine A, Strauss V, Walk T, Wiemer J (2012): Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals – From QSAR to QBAR. Mutation Research / Genetic Toxicology and Environmental Mutagenesis 746, 144-150. 

Balcke GU, Kolle S, Kamp H, Bethan B, Looser R, Wagner S, Landsiedel R, van Ravenzwaay B (2011): Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach. Toxicology Letters 203, 200-209.

Colyer A, Gilham MS, Kamlage B, Rein D, Allaway D (2011): Identification of intra- and inter-individual metabolite variation in plasma metabolite profiles of cats and dogs. British Journal of Nutrition 106, 146-149.

Duke S, Evidente A, Fiore M, Rimando A, Dayan F, Vurro M, Christiansen N, Looser R, Hutzler J, Grossmann K (2011): Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata. Pesticide Biochemistry and Physiology 100, 41-50.

Jentzmik F, Stephan C, Lein M, Miller K, Kamlage B, Bethan B, Kristiansen G, Jung K (2011): Sarcosine in prostate cancer tissue is not a differential metabolite for prostate cancer aggressiveness and biochemical progression. The Journal of Urology 185, 706-711.

Mellert W, Kapp M, Strauss V, Wiemer J, Kamp H, Walk T, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2011): Nutritional impact on the plasma metabolome of rats. Toxicology Letters 207, 173-181.

Pick TR, Bräutigam A, Schlüter U, Denton AK, Colmsee C, Scholz U, Fahnenstich H, Pieruschka R, Rascher U, Sonnewald U, Weber AP (2011): Systems analysis of a maize leaf developmental gradient redefines the current C4 model and provides candidates for regulation. Plant Cell 23, 4208-4220.

2010

Grossmann K, Niggeweg R, Christiansen N, Looser R, Ehrhardt T (2010): The herbicide Saflufenacil (KixorTM) is a new inhibitor of protoporphyrinogen IX oxidase activity. Weed Science 58, 1-9.

Haufe S, Engeli S, Budziarek P, Utz W, Schulz-Menger J, Hermsdorf M, Wiesner S, Otto C, Fuhrmann JC, Luft FC, Boschmann M, Jordan J (2010): Determinants of exercise-induced fat oxidation in obese women and men. Hormone and Metabolic Research 42, 215-221.

van Ravenzwaay B, Cunha GC-P, Fabian E, Herold M, Kamp H, Krennrich G, Krotzky A, Leibold E, Looser R, Mellert W, Prokoudine A, Strauss V, Trethewey R, Walk T, Wiemer J (2010): The use of metabolomics in cancer research. In: Cho WCS (ed.): An Omics Perspective on Cancer Research. pp 141-166. Springer, Dordrecht.

van Ravenzwaay B, Cunha GC-P, Strauss V, Wiemer J, Leibold E, Kamp H, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M (2010): The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di(2-ethylhexyl)phthalate following a 28-day dietary exposure in rats. Toxicology Letters 198, 159-170. 

Kamp H, Buesen R, Cunha GC-P, Fabian E, Fischer W, Herold M, Leibold E, Looser R, Krennrich G, Mellert W, Nishino T, Prokoudine A, Strauss V, Walk T, Wiemer J, van Ravenzwaay B (2009): Metabolite profiling – A new tool for the identification of toxicological effects of chemicals. Toxicology Letters 189, S31-S32.

Martin FPJ, Rezzi S, Peré-Trepat E, Kamlage B, Collino S, Leibold E, Kastler J, Rein D, Fay LB, Kochhar S (2009): Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. Journal of Proteome Research 8, 5568-5579.

Mutch DM, Fuhrmann JC, Rein D, Wiemer J, Bouillot JL, Poitou C, Clément K (2009): Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. PLoS ONE 4, e7905. doi: 10.1371/journal.pone.0007905.

Strauss V, Wiemer J, Leibold E, Kamp H, Walk T, Mellert W, Looser R, Prokoudine A, Fabian E, Krennrich G, Herold M, van Ravenzwaay B (2009): Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies. Toxicology Letters 191, 88-95.

Usadel B, Bläsing OE, Gibon Y, Poree F, Höhne M, Günter M, Trethewey R, Kamlage B, Poorter H, Stitt M (2008): Multilevel genomic analysis of the response of transcripts, enzyme activities and metabolites in Arabidopsis rosettes to a progressive decrease of temperature in the non-freezing range. Plant, Cell and Environment 31, 518–547.

Osuna D, Usadel B, Morcuende R, Gibon Y, Bläsing OE, Höhne M, Günter M, Kamlage B, Trethewey R, Scheible W-R, Stitt M (2008): Temporal responses of transcripts, enzyme activities and metabolites after adding sucrose to carbon-deprived Arabidopsis seedlings. The Plant Journal 49, 463-491.

Trethewey RN, Krotzky AJ (2007): Metabolic Profiling: Applications in Plant Science. In: Lindon JC, Nicholson JK, Holmes E (eds.): The Handbook of Metabonomics and Metabolomics. pp. 443-487. Elsevier, Amsterdam.

van Ravenzwaay B, Cunha GC-P, Leibold E, Looser R, Mellert W, Prokoudine A, Walk T, Wiemer J (2008): The use of metabolomics for the discovery of new biomarkers of effect. Toxicology Letters 172, 21-28.

Gibon Y, Usadel B, Bläsing OE, Kamlage B, Höhne M, Trethewey RN, Stitt M (2006): Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. Genome Biology 7, R76. doi: 10.1186/gb-2006-7-8-r76.

Trethewey RN (2006): Plant metabolite profiling for industrial applications. In: Saito K, Dixon RA, Willmitzer L (eds.): Plant Metabolomics. pp. 327-339. Springer, Berlin. 

Fernie AR, Trethewey RN, Krotzky AJ, Willmitzer L (2004): Metabolite profiling: from diagnostics to systems biology. Nature Reviews Molecular Cell Biology 5, 763-768.

Trethewey RN (2001): Gene discovery via metabolic profiling. Current Opinion in Biotechnology 12, 135-138. 

Trethewey RN, Krotzky AJ, Willmitzer L (1999): Metabolic profiling: a Rosetta Stone for genomics? Current Opinion in Plant Biology 2, 83-85.